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Sleep and Resilience

Sleep and Resilience

In collaboration with the Walter Reed Army Institute of Research, we are developing individual-specific phenomenological models to predict the effects of total sleep deprivation and chronic sleep restriction on human alertness and performance. We are also exploring how best to incorporate into these models the effects of performance-restoring countermeasures, such as naps, caffeine, and wake-promoting drugs. Moreover, we are attempting to develop analytic tools to categorize distinct sleep-loss phenotypes and associations between resilience to sleep loss and stress markers, such as cortisol.

Publications

Reifman, J., K. Kumar, N. J. Wesensten, N. A. Tountas, T. J. Balkin, and S. Ramakrishnan. 2B-Alert Web: an open-access tool for predicting the effects of sleep/wake schedules and caffeine consumption on neurobehavioral performance. Sleep. 2016 December 1; 39(12):2157-2159. [PDF 436 KB]

Ramakrishnan, S., N. J. Wesensten, G. H. Kamimori, J. E. Moon, T. J. Balkin, and J. Reifman. A unified model of performance for predicting the effects of sleep and caffeine. Sleep. 2016 October 1; 39(10):1827-1841. [PDF 2624 KB]

Ramakrishnan, S., N. J. Wesensten, T. J. Balkin, and J. Reifman. A unified model of performance: validation of its predictions across different sleep/wake schedules. Sleep. 2016 January 1; 39(1):249-262. [PDF 1183 KB]

Ramakrishnan, S., S. Laxminarayan, N. J. Wesensten, T. J. Balkin, and J. Reifman. Can we predict cognitive performance decrements due to sleep loss and the recuperative effects of caffeine? Proceedings of the HFM-254 Symposium on Health Surveillance and Informatics in Missions: Multidisciplinary Approaches and Perspectives. Paris, France. 2015 October 12-14; 20:1-20. [PDF 760 KB]

Ramakrishnan, S., W. Lu, S. Laxminarayan, N. J. Wesensten, T. L. Rupp, T. J. Balkin, and J. Reifman. Can a mathematical model predict an individual's trait-like response to both total and partial sleep loss? Journal of Sleep Research. 2015 June; 24(3):262-269. [PDF 303 KB]

Ramakrishnan, S., S. Laxminarayan, N. J. Wesensten, G. H. Kamimori, T. J. Balkin, and J. Reifman. Dose-dependent model of caffeine effects on human vigilance during total sleep deprivation. Journal of Theoretical Biology. 2014 October 7; 358:11-24. [PDF 774 KB]

Rajdev, P., D. Thorsley, S. Rajaraman, T. L. Rupp, N. J. Wesensten, T. J. Balkin, and J. Reifman. A unified mathematical model to quantify performance impairment for both chronic sleep restriction and total sleep deprivation. Journal of Theoretical Biology. 2013 April 24; 331:66-77. [PDF 1371 KB]

Ramakrishnan, S., S. Rajaraman, S. Laxminarayan, N. J. Wesensten, G. H. Kamimori, T. J. Balkin, and J. Reifman. A biomathematical model of the restoring effects of caffeine on cognitive performance during sleep deprivation. Journal of Theoretical Biology. 2013 February 21; 319:23-33. [PDF 542 KB]

Rajaraman, S., S. Ramakrishnan, D. Thorsley, N. Wesensten, T. Balkin, and J. Reifman. A new metric for quantifying performance impairment on the psychomotor vigilance test. Journal of Sleep Research. 2012 December; 21(6):659-674. [PDF 1012 KB]

Thorsley, D., R. Leproult, K. Spiegel, and J. Reifman. A phenomenological model for circadian and sleep allostatic modulation of plasma cortisol concentration. American Journal of Physiology - Endocrinology and Metabolism. 2012 November; 303(10):E1190-1201. [PDF 816 KB]

Ramakrishnan, S., S. Laxminarayan, D. Thorsley, N. J. Wesensten, T. J. Balkin, and J. Reifman. Individualized performance prediction during total sleep deprivation: accounting for trait vulnerability to sleep loss. Proceedings of the 34th IEEE EMBS Annual International Conference. San Diego, CA. 2012 August 28-September 1; 5574-5577. [PDF 634 KB]

Rajaraman, S., N. J. Wesensten, T. J. Balkin, and J. Reifman. Individualized management of fatigue and cognitive performance impairment through biomathematical modeling. Proceedings of the RTO HFM Symposium on Human Performance Enhancement for NATO Military Operations (Science, Technology, and Ethics). Sofia, Bulgaria. 2009 October 5-7; 28:1-11. [PDF 151 KB]

Rajaraman, S., A. V. Gribok, N. J. Wesensten, T. J. Balkin, and J. Reifman. An improved methodology for individualized performance prediction of sleep-deprived individuals with the two-process model. Sleep. 2009 October 1; 32(10):1377-1392. [PDF 319 KB]

Rajaraman, S., A. V. Gribok, N. J. Wesensten, T. J. Balkin, and J. Reifman. Individualized performance prediction of sleep-deprived individuals with the two-process model. Journal of Applied Physiology. 2008 February; 104(2):459-468. [PDF 664 KB]

Reifman, J., S. Rajaraman, and A. V. Gribok. Moving towards individualized performance models. Sleep. 2007 September 1; 30(9):1081-1082. [PDF 150 KB]

Reifman, J. Alternative methods for modeling fatigue and performance. Aviation, Space, and Environmental Medicine. 2004 March; 75(3):A173-180. [PDF 206 KB]

Reifman, J., and P. Gander. Commentary on the three-process model of alertness and broader modeling issues. Aviation, Space, and Environmental Medicine. 2004 March; 75(3):A84-88. [PDF 59 KB]