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Network Science & Systems Biology

Our research aims at understanding how different cellular and biological phenotypes arise from an underlying network description of biological components. The projects we develop in this area include how to use the fundamental aspects of protein-protein interactions and metabolic networks to model prokaryotic and eukaryotic cellular processes. We can then apply these and other systems biology techniques to address military medical questions related to infectious diseases, blood coagulation, and wound healing.

Research Projects

Brain Injury Biomarkers Brain Injury Biomarkers

This research uses systems biology concepts to gain insights into the molecular mechanisms of traumatic brain injury (TBI) and identify protein biomarkers.

Blood Coagulation Blood Coagulation

We are performing quantitative studies of trauma-induced blood coagulopathy and designing improved therapeutic strategies to treat uncontrollable hemorrhaging.

Inflammation Inflammation

Our goal is to identify key biochemical components and interactions that determine the physiological consequences of inflammation.

Metabolic Networks Metabolic Networks

By exploiting cellular metabolism, we can predict gene essentiality, the effect of drug cocktails, and the metabolic changes associated with stress.

Protein-Protein Interactions Protein-Protein Interactions

This research examines the fundamental properties of protein-protein interaction networks to gain insights into the biological processes that mediate diseases.

Wound Healing Wound Healing

Understanding how the body can repair itself provides insights into how wounded patients can escape chronic healing, heal faster, and minimize scarring.