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Glucose Modeling and Control

Glucose Modeling and Control

With the long-term goal of contributing to the development of an "artificial pancreas," we are developing algorithms that, when integrated with continuous glucose monitoring systems, allow for proactive interventions (i.e., adjustment of insulin delivery or intake of glucose) to prevent undesirable hypo- and hyperglycemic episodes.

Publications

Laxminarayan, S., J. Reifman, S. S. Edwards, H. Wolpert, and G. M. Steil. Bolus estimation - rethinking the effect of meal fat content. Diabetes Technology and Therapeutics. 2015 December; 17(12):860-866. [PDF 206 KB]

Laxminarayan, S., J. Reifman, and G. M. Steil. Use of a food and drug administration-approved type 1 diabetes mellitus simulator to evaluate and optimize a proportional-integral-derivative controller. Journal of Diabetes Science and Technology. 2012 November; 6(6):1401-1412. [PDF 2885 KB]

Lu, Y., S. Rajaraman, W. K. Ward, R. A. Vigersky, and J. Reifman. Predicting human subcutaneous glucose concentration in real time: a universal data-driven approach. Proceedings of the 33rd IEEE EMBS Annual International Conference. Boston, MA. 2011 August 30-September 3; 7945-7948. [PDF 501 KB]

Steil, G. M., B. Hipszer, and J. Reifman. Update on mathematical modeling research to support the development of automated insulin delivery systems. Journal of Diabetes Science and Technology. 2010 May; 4(3):759-769. [PDF 297 KB]

Lu, Y., A. V. Gribok, W. K. Ward, and J. Reifman. The importance of different frequency bands in predicting subcutaneous glucose concentration in type 1 diabetic patients. IEEE Transactions on Biomedical Engineering. 2010 April 15; 57(8):1839-1846. [PDF 363 KB]

Gani, A., A. V. Gribok, Y. Lu, W. K. Ward, R. A. Vigersky, and J. Reifman. Universal glucose models for predicting subcutaneous glucose concentration in humans. IEEE Transactions on Information Technology in Biomedicine. 2010 January; 14(1):157-165. [PDF 566 KB]

Steil, G. M., and J. Reifman. Mathematical modeling research to support the development of automated insulin-delivery systems. Journal of Diabetes Science and Technology. 2009 March; 3(2):388-395. [PDF 300 KB]

Gani, A., A. V. Gribok, S. Rajaraman, W. K. Ward, and J. Reifman. Predicting subcutaneous glucose concentration in humans: data-driven glucose modeling. IEEE Transactions on Biomedical Engineering. 2009 February; 56(2):246-254. [PDF 374 KB]

Reifman, J., S. Rajaraman, A. Gribok, and W. K. Ward. Predictive Monitoring for improved management of glucose levels. Journal of Diabetes Science and Technology. 2007 July; 1(4):478-486. [PDF 1122 KB]