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Acute and chronic inflammation impedes a Warfighter's performance and health. We aim to identify key biochemical components and interactions that determine the physiological consequences of inflammation and reveal biochemical predictors of disease progression and outcomes in, e.g., heat stroke, musculoskeletal injury, and viral or bacterial infections.


Nagaraja, S., L. Chen, J. Zhou, Y. Zhao, D. Fine, L. A. DiPietro, J. Reifman, and A. Y. Mitrophanov. Predictive analysis of mechanistic triggers and mitigation strategies for pathological scarring in skin wounds. Journal of Immunology. 2017 January 15; 198(2):832-841. [PDF 1264 KB]

Tomaiuolo, M., M. Kottke, R. W. Matheny, J. Reifman, and A. Y. Mitrophanov. Computational identification and analysis of signaling subnetworks with distinct functional roles in the regulation of TNF production. Molecular BioSystems. 2016 March 1; 12(3):826-838. [PDF 2656 KB]

Nagaraja, S., J. Reifman, and A. Y. Mitrophanov. Computational identification of mechanistic factors that determine the timing and intensity of the inflammatory response. PLOS Computational Biology. 2015 December 3; 11(12):e1004460. [PDF 2403 KB]

Scheff, J. D., J. D. Stallings, J. Reifman, and V. Rakesh. Mathematical modeling of the heat-shock response in HeLa cells. Biophysical Journal. 2015 July 12; 109(2):182-193. [PDF 1259 KB]

Ippolito, D. L., J. A. Lewis, C. Yu, L. R. Leon, and J. D. Stallings. Alteration in circulating metabolites during and after heat stress in the conscious rat: potential biomarkers of exposure and organ-specific injury. BMC Physiology. 2014 December 24; 14:14. [PDF 3516 KB]

Stallings, J. D., D. L. Ippolito, V. Rakesh, C. E. Baer, W. E. Dennis, B. G. Helwig, D. A. Jackson, L. R. Leon, J. A. Lewis, and J. Reifman. Patterns of gene expression associated with recovery and injury in heat-stressed rats. BMC Genomics. 2014 December 3; 15:1058. [PDF 2794 KB]

Rakesh, V., J. D. Stallings, and J. Reifman. A virtual rat for simulating environmental and exertional heat stress. Journal of Applied Physiology. 2014 December 1; 117(11):1278-1286. [PDF 775 KB]

Nagaraja, S., A. Wallqvist, J. Reifman, and A. Y. Mitrophanov. Computational approach to characterize causative factors and molecular indicators of chronic wound inflammation. Journal of Immunology. 2014 February 15; 192(4):1824-1834. [PDF 1365 KB]

Rakesh, V., J. D. Stallings, B. G. Helwig, L. R. Leon, D. A. Jackson, and J. Reifman. A 3-D mathematical model to identify organ-specific risks in rats during thermal stress. Journal of Applied Physiology. 2013 December 15; 115(12):1822-1837. [PDF 1692 KB]