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Blood Coagulation

Blood Coagulation

The blood coagulation system comprises a large number of biochemical and cellular interactions that are involved in the formation of a blood clot at the site of vascular injury. Our work, which focuses on trauma-induced coagulopathy, aims to 1) investigate the quantitative differences between normal and pathological blood clotting, 2) elucidate the contributions of hypothermia and acidosis to coagulopathy, and 3) design strategies to modulate the blood coagulation process by therapeutic interventions.

Publications

Mitrophanov, A. Y., F. Szlam, R. M. Sniecinski, J. H. Levy, and J. Reifman. In reply to "If the goal is balance, why not fresh frozen plasma?" Anesthesia & Analgesia. 2017 February; 124(2):699-700. [PDF 882 KB]

Mitrophanov, A. Y., F. Szlam, R. M. Sniecinski, J. H. Levy, and J. Reifman. In reply to "Clinical and practical aspects of restoring thrombin generation in acute coagulopathic bleeding." Anesthesia & Analgesia. 2017 February; 124(2):702. [PDF 866 KB]

Mitrophanov, A. Y., F. Szlam, R. M. Sniecinski, J. H. Levy, and J. Reifman. A step toward balance: thrombin generation improvement via procoagulant factor and antithrombin supplementation. Anesth Analg. 2016 September; 123(3):535-546. [PDF 1403 KB]

Govindarajan, V., V. Rakesh, J. Reifman, and A. Y. Mitrophanov. Computational study of thrombus formation and clotting factor effects under venous flow conditions. Biophysical Journal. 2016 April 26; 110(8):1869-1885. [PDF 2340 KB]

Mitrophanov, A. Y., F. R. Rosendaal, and J. Reifman. Mechanistic modeling of the effects of acidosis on thrombin generation. Anesthesia & Analgesia. 2015 August; 121(2):278-288. [PDF 1700 KB]

Mitrophanov, A. Y., A. S. Wolberg, and J. Reifman. Kinetic model facilitates analysis of fibrin generation and its modulation by clotting factors: implications for hemostasis-enhancing therapies. Molecular BioSystems. 2014 June 24; 10:2347-2357. [PDF 1815 KB]

Mitrophanov, A. Y., F. R. Rosendaal, and J. Reifman. Computational analysis of the effects of reduced temperature on thrombin generation: the contributions of hypothermia to coagulopathy. Anesthesia & Analgesia. 2013 September; 117(3):565-574. [PDF 1460 KB]

Mitrophanov, A. Y., F. R. Rosendaal, and J. Reifman. Computational analysis of intersubject variability and thrombin generation in dilutional coagulopathy. Transfusion. 2012 November; 52(11):2475-2486. [PDF 696 KB]

Mitrophanov, A. Y., F. R. Rosendaal, and J. Reifman. Therapeutic correction of thrombin generation in dilution-induced coagulopathy: computational analysis based on a data set of healthy subjects. The Journal of Trauma and Acute Care Surgery. 2012 August; 73(2 Suppl 1):S95-102. [PDF 1448 KB]

Mitrophanov, A. Y., and J. Reifman. Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation. Thrombosis Research. 2011 October; 128(4):381-390. [PDF 919 KB]