The establishment of traumatic brain injury (TBI) biomarkers is a key step in the development of diagnostic assays that assess acute brain injury. This project mines existing high-throughput proteomics, gene expression, and protein-protein interaction data sets to identify brain pathways affected by TBI and extract novel brain injury-specific protein biomarkers. We can then experimentally verify the identified putative biomarkers in injury-specific animal models, such as the penetrating ballistic-like brain injury (PBBI) murine model.
Yu, C., A. Boutte, X. Yu, B. Dutta, J. D. Feala, K. Schmid, J. Dave, G. J. Tawa, A. Wallqvist, and J. Reifman. A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury. Journal of Neuroscience Research. 2015 February; 93(2):199-214. [PDF 1079 KB]
Feala, J. D., M. D. AbdulHameed, C. Yu, B. Dutta, X. Yu, K. Schmid, J. Dave, F. Tortella, and J. Reifman. Systems biology approaches for discovering biomarkers for traumatic brain injury. Journal of Neurotrauma. 2013 July 1; 30(13):1101-1116. [PDF 344 KB]