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Blast-induced Traumatic Brain Injury

To date, there is no consensus on whether or how exposure to blast waves (i.e., exposure to blast overpressure) causes mild traumatic brain injury. Without such an understanding, we cannot develop effective strategies that prevent, or provide protection against, this type of injury. We perform experimental studies to support the development and validation of high-fidelity finite-element biomechanical models, through which we investigate and quantify the effects of various potential mechanisms of blast-induced traumatic brain injury.


Unnikrishnan, G., H. Mao, A. Sundaramurthy, E. D. Bell, S. Yeoh, K. Monson, and J. Reifman. A 3-D rat brain model for blast-wave exposure: effects of brain vasculature and material properties. Annals of Biomedical Engineering. 2019 May 3; [Epub ahead of print]. [PDF, PubMed]

Bell, E. D., M. Converse, H. Mao, G. Unnikrishnan, J. Reifman, and K. L. Monson. Material properties of rat middle cerebral arteries at high strain rates. Journal of Biomechanical Engineering. 2018 July 1; 140(7):071004. [PDF, PubMed]

Mao, H., G. Unnikrishnan, V. Rakesh, and J. Reifman. Untangling the effect of head acceleration on brain responses to blast waves. Journal of Biomechanical Engineering. 2015 December 1; 137(12):124502. [PDF, PubMed]