Our research is organized into three main objectives: 1) establish theoretical foundations for understanding virus escape mutations under the T cell-mediated immune response, 2) determine the extent to which the theoretical concepts allow for quantitative descriptions of immune escape in model viruses, and 3) evaluate hypotheses for the effects of immune escape characteristics on disease pathogenesis and explore their implications for vaccine design.
Woo, H. J., and J. Reifman. Quantitative modeling of virus evolutionary dynamics and adaptation in serial passages using empirically inferred fitness landscapes. Journal of Virology. 2014 January; 88(2):1039-1050. [PDF 698 KB]
Woo, H. J., and J. Reifman. A quantitative quasispecies theory-based model of virus escape mutation under immune selection. Proceedings of the National Academy of Sciences of the United States of America. 2012 August 7; 109(32):12980-12985. [PDF 393 KB]
Woo, H. J., R. Vijaya Satya, and J. Reifman. Thermodynamic basis for the emergence of genomes during prebiotic evolution. PLOS Computational Biology. 2012 May; 8(5):e1002534. [PDF 1370 KB]
Woo, H. J., and A. Wallqvist. Nonequilibrium phase transitions associated with DNA replication. Physical Review Letters. 2011 February 11; 106:060601. [PDF 283 KB]