CLINICAL VACCINE RESEARCH

Vaccine clinical trials often generate a large number of immune measures at multiple time points. By using data from such trials, we develop new computational methods to carry out 1) univariate and correlation analyses, 2) multivariate analysis, and 3) mathematical modeling to identify potential correlates of protection or mechanisms of action in vaccine studies. We work closely with clinical collaborators on a range of infectious diseases, including malaria and dengue fever.

Publications

Andagalu, B., P. Lu, I. Onyango, E. Bergmann-Leitner, R. Wasuna, G. Odhiambo, L. J. Chebon-Bore, L. A. Ingasia, D. W. Juma, B. Opot, A. Cheruiyot, R. Yeda, C. Okudo, R. Okoth, G. Chemwor, J. Campo, A. Wallqvist, H. M. Akala, D. Ochiel, B. Ogutu, S. Chaudhury, and E. Kamau. Age-dependent antibody profiles to plasmodium antigens are differentially associated with two artemisinin combination therapy outcomes in high transmission setting. Frontiers in Medicine. 2022 October 13; 9:991807. [PDF, Pubmed]

Mura, M., P. Lu, T. Atre, J. S. Bolton, E. H. Duncan, S. Chaudhury, and E. S. Bergmann-Leitner. Immunoprofiling identifies functional B and T cell subsets induced by an attenuated whole parasite malaria vaccine as correlates of sterile immunity. Vaccines. 2022 January 14; 10(1):124. [PDF, PubMed]

Lu, P., D. J. Guerin, S. Lin, S. Chaudhury, M. E. Ackerman, D. L. Bolton, and A. Wallqvist. Immunoprofiling correlates of protection against SHIV infection in adjuvanted HIV-1 pox-protein vaccinated rhesus macaques. Frontiers in Immunology. 2021 May 11; 12:625030. [PDF, PubMed]

Hickey, B., N. Teneza-Mora, J. Lumsden, S. Reyes, M. Sedegah, L. Garver, M. R. Hollingdale, J. G. Banania, H. Ganeshan, M. Dowler, A. Reyes, C. Tamminga, A. Singer, A. Simmons, M. Belmonte, A. Belmonte, J. Huang, S. Inoue, R. Velasco, S. Abot, C. S. Vasquez, I. Guzman, M. Wong, P. Twomey, M. Wojnarski, J. Moon, Y. Alcorta, S. Maiolatesi, M. Spring, S. Davidson, S. Chaudhury, E. Villasante, T. L. Richie, and J. E. Epstein. IMRAS-A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents. PLOS ONE. 2020 June 20; 15(6):e0233840. [PDF, PubMed]

Pallikkuth, S., S. Chaudhury, P. Lu, L. Pan, E. Jongert, U. Wille-Reece, and S. Pahwa. A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses. Elife. 2020 April 29; 9:e51889. [PDF, PubMed]

Bolton, J. S., S. Chaudhury, S. Dutta, S. Gregory, E. Locke, T. Pierson, and E. S. Bergmann-Leitner. Comparison of ELISA with electro-chemiluminescence technology for the qualitative and quantitative assessment of serological responses to vaccination. Malaria Journal. 2020 April 17; 19(1):159. [PDF, PubMed]

Chaudhury, S., E. H. Duncan, T. Atre, S. Dutta, M. D. Spring, W. W. Leitner, and E. S. Bergmann-Leitner. Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity. Human Vaccines & Immunotherapeutics. 2020 February 25; 16(2):400-411. [PDF, PubMed]

Chaudhury, S., E. H. Duncan, T. Atre, C. K. Storme, K. Beck, S. A. Kaba, D. E. Lanar, and E. S. Bergmann-Leitner. Identification of immune signatures of novel adjuvant formulations using machine learning. Scientific Reports. 2018 November 30; 8(1):17508. [PDF, PubMed]

Chaudhury, S., J. A. Regules, C. A. Darko, S. Dutta, A. Wallqvist, N. C. Waters, E. Jongert, F. Lemiale, and E. S. Bergmann-Leitner. Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis. Scientific Reports. 2017 August 11; 7:7998. [PDF, PubMed]

Chaudhury, S., C. F. Ockenhouse, J. A. Regules, S. Dutta, A. Wallqvist, E. Jongert, N. C. Waters, F. Lemiale, and E. Bergmann-Leitner. The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity. Malaria Journal. 2016 May 31; 15:301. [PDF, PubMed]