We model molecular toxicity pathways to understand how chemicals affect biological systems and develop methods that systematize the analysis of large amounts of high-throughput data to predict their toxic effects. These tools facilitate countermeasure development and provide diagnostics for toxic exposure. We aim to discover biomarkers; identify organ-specific injury signatures and metabolite profiles associated with toxic insults; and develop in silico models for Adsorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) endpoints.
Biomarkers & Molecular Toxicity Pathways
This research uses a systems-based approach to identify omics signatures and biomarkers indicative of injuries to organs, such as the liver and kidney.
Predictive ADMET Modeling
We develop in silico models that enable rapid high-throughput screening of compounds to assess mutagenicity, cardiac toxicity, and drug metabolism.