Clot formation in a blood vessel is shaped by the interplay between biochemical reactions, cellular processes, and blood flow properties. The flow properties are defined by blood pressure, vessel shape and size, and the growing clot itself. We investigate how these distinct factors determine the structural and mechanical characteristics of the clot. Our ultimate goal is to develop computational strategies that rapidly identify promising therapeutic approaches for traumatic coagulopathy.
Mitrophanov, A. Y., G. Merrill-Skoloff, S. P. Grover, V. Govindarajan, A. Kolanjiyil, D. S. Hariprasad, G. Unnikrishnan, R. Flaumenhaft, and J. Reifman. Injury length and arteriole constriction shape clot growth and blood-flow acceleration in a mouse model of thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 September; 40(9):2114-2126. [PDF, PubMed]
Mitrophanov, A. Y., F. Szlam, R. M. Sniecinski, J. H. Levy, and J. Reifman. Controlled multifactorial coagulopathy: effects of dilution, hypothermia, and acidosis on thrombin generation in vitro. Anesthesia & Analgesia. 2020 April; 130(4):1063-1076. [PDF, PubMed]
Mitrophanov, A. Y., V. Govindarajan, S. Zhu, R. Li, Y. Lu, S. L. Diamond, and J. Reifman. Microfluidic and computational study of structural properties and resistance to flow of blood clots under arterial shear. Biomechanics and Modeling in Mechanobiology. 2019 October; 18(5):1461-1474. [PDF, PubMed]
Govindarajan, V., S. Zhu, R. Li, Y. Lu, S. L. Diamond, J. Reifman, and A. Y. Mitrophanov. Impact of tissue factor localization on blood clot structure and resistance under venous shear. Biophysical Journal. 2018 February 27; 114(4):978-991. [PDF, PubMed]
Govindarajan, V., V. Rakesh, J. Reifman, and A. Y. Mitrophanov. Computational study of thrombus formation and clotting factor effects under venous flow conditions. Biophysical Journal. 2016 April 26; 110(8):1869-1885. [PDF, PubMed]