We use in-house data analysis and modeling tools to characterize immune responses to early-stage vaccine candidates in animal or in vitro infection models. Research areas include 1) antigen discovery and selection, 2) epitope mapping and antigen design, and 3) statistical analysis and modeling of immune assay data. We participate in a wide range of pre-clinical studies of vaccines for diseases, such as malaria, dengue fever, glanders, and Ebola infection.
Mitchell, D. A. J., L. C. Dupuy, M. Sanchez-Lockhart, G. Palacios, J. W. Back, K. Shimanovskaya, S. Chaudhury, D. R. Ripoll, A. Wallqvist, and C. S. Schmaljohn. Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice. Human Vaccines & Immunotherapeutics. 2017 December 2; 13(12):2883-2893. [PDF]
Ripoll, D. R., D. A. J. Mitchell, L. C. Dupuy, A. Wallqvist, C. Schmaljohn, and S. Chaudhury. Combinatorial peptide-based epitope mapping from Ebola virus DNA vaccines and infections reveals residue-level determinants of antibody binding. Human Vaccines & Immunotherapeutics. 2017 December 2; 13(12):2953-2966. [PDF]
Khavrutskii, I. V., S. Chaudhury, S. M. Stronsky, D. W. Lee, J. G. Benko, A. Wallqvist, S. Bavari, and C. L. Cooper. Quantitative analysis of repertoire-scale immunoglobulin properties in vaccine-induced B-cell responses. Frontiers in Immunology. 2017 August 14; 8:910. [PDF]
Bozue, J. A., S. Chaudhury, K. Amemiya, J. Chua, C. K. Cote, R. G. Toothman, J. L. Dankmeyer, C. P. Klimko, C. L. Wilhemsen, J. L. Raymond, N. Zavaljevski, J. Reifman, and A. Wallqvist. Phenotypic characterization of a novel virulence-factor deletion strain of Burkholderia mallei that protects against aerosolized glanders in mice. Frontiers in Cellular and Infection Microbiology. 2016 February 26; 6:21. [PDF]
Chaudhury, S., J. Reifman, and A. Wallqvist. Simulation of B cell affinity maturation explains enhanced antibody cross-reactivity induced by the polyvalent malaria vaccine AMA1. Journal of Immunology. 2014 September 1; 193(5):2073-2086. [PDF]
Bergmann-Leitner, E. S., S. Chaudhury, N. J. Steers, M. Sabato, V. Delvecchio, A. S. Wallqvist, C. F. Ockenhouse, and E. Angov. Computational and experimental validation of B and T-cell epitopes of the in vivo immune response to a novel malarial antigen. PLOS ONE. 2013 August 16; 8(8):e71610. [PDF]